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3. Production AND Application OF ANGIOSTATINS FOR THE Treatment OF OCULAR NEOVASCULAR DESEASE

Production AND APPLICATION OF ANGIOSTATINS FOR THE Handling OF OCULAR NEOVASCULAR DESEASES

Biotechnologia Acta ; fourteen(1):5-24, 2021.

Artigo em Inglês

| ProQuest Central | ID: covidwho-1136887

• Abstruse

Abstruse

Angiostatins comprise a group of kringle-containing proteolytically-derived fragments of plasminogen/plasmin, which act equally strong inhibitory mediators of endothelial cells proliferation and migration. Angiostatins are involved in modulation of vessel growth in good for you tissues and various pathological conditions associated with aberrant neovascularization. The aim of the present paper was to summarize available information, including our own experimental data, on prospects of angiostatin application for handling of ocular neovascular diseases (OND), focusing on retinal pathologies and corneal injury. In particular, literature data on prospective and retrospective studies, clinical trials and creature models relating to the pathophysiology, investigation and management of OND are described. Special accent was made on the laboratory approaches of production of dissimilar angiostatin isoforms, as well as comparison of antiangiogenic capacities of native and recombinant angiostatin polypeptides. Several studies reported that angiostatins may completely abolish pathologic angiogenesis in diabetic proliferative retinopathy without affecting normal retinal vessel development and without exhibiting adverse side furnishings. Angiostatins accept been tested as a tool for corneal antiangiogenesis target therapy in order to manage diverse ocular surface pathological atmospheric condition induced by traumas, chemical burns, previous surgery, chronic contact lens clothing, autoimmune diseases, keratitis and viral infections (herpes, COVID-19), corneal graft rejection, etc. Among all known angiostatin species, isolated K5 plasminogen fragment was shown to display the well-nigh strong inhibitory action confronting proliferation of endothelial cells via triggering multiple signaling pathways, which atomic number 82 to cell death and resulting angiogenesis suppression. Application of adenoviral genetic construct encoding angiostatin K5 as a promising tool for OND treatment illustrates a bright case of upcoming revolution in local gene therapy. Further comprehensive studies are necessary to elucidate the clinical potential and optimal regimes of angiostatin-based intervention modalities for treating ocular neovascularization.Alternating abstractАнгÃ'‚Ã'Ã'‚аÃ'‚ини Ã'Ã'‚ановлÃ'Ã'‚Ã'Å' Ã'‚Ã'€Ã'Æ'пÃ'Æ' кÃ'€Ð¸Ð½Ð³Ð»(К)-вм1Ã'Ð½Ð¸Ã'… пÃ'€Ð¾Ã'‚еол1Ã'‚иÃ'‡Ð½Ð¸Ã'… Ã'„Ã'€Ð°Ð³Ð¼ÐµÐ½Ã'‚Ã'ˆ плазмÃ'ˆÐ¾Ð³ÐµÐ½/плазмÃ'ˆÃ'Æ', Ã'Ðº1 Ã'„Ã'Æ'нкÃ'‰Ð¾Ð½Ã'Æ'Ã'ŽÃ'‚Ã'Å' Ã'Ðº поÃ'‚Ã'Æ'жÃ'ˆ Ã'ˆÐ¿Ð±Ã'Æ'валÃ'Å'Ã'ˆ медÃ'‚Ã'‚оÃ'€Ð¸ пÃ'€Ð¾Ð»1Ã'„еÃ'€Ð°Ã'†Ð¿ Ã'‚а Mirpauii ендоÃ'‚елÃ'ˆÐ½Ð¸Ã'… клггин. Вони беÃ'€Ã'Æ'Ã'‚Ã'Å' Ã'Æ'Ã'‡Ð°Ã'Ã'‚Ã'Å' Ã'Æ' модÃ'Æ'лÃ'ŽÐ²Ð°Ð½Ã'ˆ Ã'€Ð¾Ã'Ã'‚Ã'Æ' Ã'Ã'Æ'дии Ã'Æ' Ã'‚канинаÃ'… за ноÃ'€Ð¼Ð¸ Ã'‚а Ã'€Ã'ŽÐ½Ð¸Ã'… паÃ'‚ологÃ'ˆÐ½Ð¸Ã'… Ã'Ã'‚анÃ'ˆ, аÃ'Ð¾Ã'†Ã'ˆÐ¾Ð²Ð°Ð½Ð¸Ã'… з абеÃ'€Ð°Ð½Ã'‚ноÃ'Ž неоваÃ'ÐºÃ'Æ'лÃ'Ã'€Ð¸Ð·Ð°Ã'‰ÐµÃ'Ž. ÐÅ"еÃ'‚оÃ'Ž Ã'€Ð¾Ð±Ð¾Ã'‚и бÃ'Æ'ло Ã'Æ'загалÃ'Å'неннÃ' наÃ'Ð²Ð½Ð¾! Ä°HÃ'„оÃ'€Ð¼Ð°Ã'†Ð¸, Ã'„оÃ'€Ð¼Ð°Ã'†Ð¸, вклÃ'ŽÃ'‡Ð°Ã'ŽÃ'‡Ð¸ влаÃ'Ã'‚ екÃ'Ð¿ÐµÃ'€Ð¸Ð¼ÐµÐ½Ã'‚алÃ'Å'HÄ° даÃ'ˆ aBTopÄ°B, Ã'‰Ð¾Ð´Ð¾ пеÃ'€Ã'Ð¿ÐµÐºÃ'‚ив заÃ'Ã'‚оÃ'Ã'Æ'ваннÃ' ангÃ'‚Ã'Ã'‚аÃ'‚инÃ'Æ' длÃ' лÃ'ˆÃ'Æ'ваннÃ' неоваÃ'ÐºÃ'Æ'лÃ'Ã'€Ð½Ð¸Ã'… заÃ'…воÃ'€Ã'ŽÐ²Ð°Ð½Ã'Å' ока (НÐâ€"О). Ð“Ð¾Ð»à ¾Ð²Ð½Ã'Æ' Ã'Æ'вагÃ'Æ' зоÃ'ÐµÃ'€ÐµÐ´Ð¶ÐµÐ½Ð¾ на паÃ'‚ологÃ'ˆÃ'… cítkíbkh Ã'‚а Ã'Æ'Ã'ˆÐºÐ¾Ð´Ð¶ÐµÐ½HÄ° porÄ°BKH. Ðâ€"окÃ'€ÐµÐ¼Ð°, опиÃ'Ð°Ð½Ð¾ даÃ'‚ Л1Ã'‚еÃ'€Ð°Ã'‚Ã'Æ'Ã'€Ð¸ Ã'Ã'‚оÃ'Ð¾Ð²Ð½Ð¾ пеÃ'€Ã'Ð¿ÐµÐºÃ'‚ивниÃ'… Ã'‚а Ã'€ÐµÃ'‚Ã'€Ð¾Ã'Ð¿ÐµÐºÃ'‚ивниÃ'… доÃ'Ð»Ã'‰Ð¶ÐµÐ½Ã'Å', клÃ'ˆÃ'ˆÐ½Ð¸Ã'… випÃ'€Ð¾Ð±Ã'Æ'ванÃ'Å' i паÃ'‚оÃ'„ÐÅ"ологÃ'ˆÐ½Ð¸Ã'… Ã'‚ваÃ'€Ð¸Ð½Ð½Ð¸Ã'… моделей, Ã'Ã'‚воÃ'€ÐµÐ½Ð¸Ã'… длÃ' доÃ'Ð»Ã'‰Ð¶ÐµÐ½Ð½Ã' Ã'‚а лÃ'ˆÃ'Æ'ваннÃ' НÐâ€"О. ОÃ'Ð¾Ð±Ð»Ð¸Ð²Ð¸Ð¹ акÃ'†ÐµÐ½Ã'‚ бÃ'Æ'ло зÃ'€Ð¾Ð±Ð»ÐµÐ½Ð¾ на лабоÃ'€Ð°Ã'‚оÃ'€Ð½Ð¸Ã'… пÃ'‰Ã'…одаÃ'… до оÃ'‚Ã'€Ð¸Ð¼Ð°Ð½Ð½Ã' Ã'€Ã'ŽÐ½Ð¸Ã'… Ã'ŽÐ¾Ã'„оÃ'€Ð¼ ангÃ'‚Ã'Ã'‚аÃ'‚инÃ'Æ', а Ã'‚акож на поÃ'€Ã'ˆÐ½Ã'Ð½Ã'ˆ анÃ'‚иангÃ'‚генниÃ'… влаÃ'Ã'‚ивоÃ'Ã'‚ей наÃ'‚ивниÃ'… Ã'‚а Ã'€ÐµÐºÐ¾Ð¼Ð±Ã'ˆÐ°Ð½Ã'‚ниÃ'… пол1пепÃ'‚идÃ'ˆ-ангÃ'‚Ã'Ã'‚аÃ'‚иÃ'ˆÐ². дÃ'ˆ-ангÃ'‚Ã'Ã'‚аÃ'‚иÃ'ˆÐ². РезÃ'Æ'лÃ'Å'Ã'‚аÃ'‚и cepii доÃ'Ð»Ã'‰Ð¶ÐµÐ½Ã'Å' Ã'Ð²1дÃ'‡Ð°Ã'‚Ã'Å', Ã'‰Ð¾Ð°Ð½Ð³Ã'‚Ã'Ã'‚аÃ' ини можÃ'Æ'Ã'‚Ã'Å' повн1Ã'Ã'‚Ã'Ž пÃ'€Ð¸Ð³Ã'ˆÃ'‡Ã'Æ'ваÃ'‚и паÃ'‚олопÃ'‡Ð½Ð¸Ð¹ анпогенез за Д1абеTH4HOÃŽ TH4HOÃŽ пÃ'€Ð¾Ð»1Ã'„еÃ'€Ð°Ã'‚ивно1 Ã'€ÐµÃ'‚инопаÃ'‚и, не впливаÃ'ŽÃ'‡Ð¸ на ноÃ'€Ð¼Ð°Ð»Ã'Å'ний Ã'€Ð¾Ð·Ð²Ð¸Ã'‚ок Ã'Ã'Æ'дин cítkíbkh Ã'‚а не виÃ'Ð²Ð»Ã'Ã'ŽÃ'‡Ð¸ неÃ'Ð¿Ã'€Ð¸Ã'Ã'‚ливиÃ'… побÃ'ˆÐ½Ð¸Ã'… еÃ'„екTÄ°B. АнпоÃ'Ã'‚аÃ'‚ини випÃ'€Ð¾Ð±Ð¾Ð²Ã'Æ'Ã'ŽÃ'‚Ã'Å' Ã'Ðº Ã'ˆÃ'Ã'‚Ã'€Ã'Æ'менÃ'‚ длÃ' Ã'‚аÃ'€Ð³ÐµÃ'‚но! анÃ'‚ианпогенно! Tepami Ã'€Ð¾Ð³Ã'ˆÐºÐ¸ з меÃ'‚оÃ'Ž лÃ'ˆÃ'Æ'ваннÃ' Ã'€Ã'ŽÐ½Ð¾Ð¼Ð°Ð½Ð³Ð³Ð½Ð¸Ã'… паÃ'‚олопÃ'‡Ð½Ð¸Ã'… Ã'Ã'‚аÃ'ˆÐ² оÃ'‡Ð½Ð¾! повеÃ'€Ã'…Ã'ˆ, Ã'Ð¿Ã'€Ð¸Ã'‡Ð¸Ð½ÐµÐ½Ð¸Ã'… Ã'‚Ã'€Ð°Ð²Ð¼Ð°Ð¼Ð¸, XÍMÍ4HHMH опÃ'ˆÐ°Ð¼Ð¸, попеÃ'€ÐµÐ´Ð½Ã'ˆÐ¸ опеÃ'€Ð°Ã'‚ивними вÃ'‚Ã'€Ã'Æ'Ã'‡Ð°Ð½Ð½Ã'Ð¼Ð¸, ПОСТШНИÐÅ" НОСШНЯÐÅ" конÃ'‚акÃ'‚ниÃ'… лÃ'ˆÐ·, авÃ'‚оÃ'ˆÃ'Æ'нними заÃ'…воÃ'€Ã'ŽÐ²Ð°Ð½Ð½Ã'Ð¼Ð¸, кеÃ'€Ð°Ã'‚иÃ'‚ами Ã'‚а вÃ'„Ã'Æ'Ã'Ð½Ð¸Ð¼Ð¸ Ã'ˆÃ'„екÃ'†Ã'ˆÐ¼Ð¸ (геÃ'€Ð¿ÐµÃ', COVID-19), вÃ'‰Ã'‚оÃ'€Ð³Ð½ÐµÐ½Ð½Ã'Ð¼ Ã'‚Ã'€Ð°Ð½Ã'Ð¿Ð»Ð°Ð½Ã'‚аÃ'‚а Ã'€Ð¾rÄ°BKH Ã'‚оÃ'‰Ð¾. СеÃ'€ÐµÐ´ ycix вÃ'‰Ð¾Ð¼Ð¸Ã'… 1зоÃ'„оÃ'€Ð¼ анпоÃ'Ã'‚аÃ'‚иÃ'ˆÐ² Ã'ŽÐ¾Ð»Ã'Å'ований Ã'„Ã'€Ð°Ð³Ð¼ÐµÐ½Ã'‚ плазмÃ'ˆÐ¾Ð³ÐµÐ½ 'Æ' К5 виÃ'Ð²Ð»Ã'Ðµ найпоÃ'‚Ã'Æ'жÃ'ˆÃ'ˆÃ'Æ' Ã'ˆÐ¿Ð±Ã'Æ'валÃ'Å'нÃ'Æ' акÃ'‚ивHÄ°CTB Ã'Ã'‚оÃ'Ð¾Ð²Ð½Ð¾ пÃ'€Ð¾Ð»1Ã'„еÃ'€Ð°Ã'†Ð¸ ендоÃ'‚елÃ'‚лÃ'Å'ниÃ'… кл1Ã'‚ин, пÃ'€Ð¸Ð³Ð½Ã'ˆÃ'Æ'Ã'ŽÃ'‡Ð¸ ĪĪ Ã'‡ÐµÃ'€ÐµÐ· акÃ'‚иваÃ'‰Ã'Ž мноÐâ€"ННННХ СНГНаЛЬННХ ШЛЯХ1Ð’, Ã'‰Ð¾ пÃ'€Ð¸Ð·Ð²Ð¾Ð´Ã'Ã'‚Ã'Å' до загибелone клггин Ã'‚а cynpecií ангÃ'ˆÐ³ÐµÐ½ÐµÐ·Ã'Æ'. Ðâ€"аÃ'Ã'‚оÃ'Ã'Æ'ваннÃ' аденовÃ'„Ã'Æ'Ã'Ð½Ð¾! генеÃ'‚иÃ'‡Ð½Ð¾! конÃ'Ã'‚Ã'€Ã'Æ'кÃ'†Ð¸, Ã'‰Ð¾ кодÃ'Æ'е ангÃ'ˆÃ'Ã'‚аÃ'‚ин К5, Ã'Ðº пеÃ'€Ã'Ð¿ÐµÐºÃ'‚ивного заÃ'Ð¾Ð±Ã'Æ' коÃ'€ÐµÐºÃ'†Ð¸ НÐâ€"О е Ã'Ã'ÐºÃ'€Ð°Ð²Ð¸Ð¼ пÃ'€Ð¸ÐºÐ»Ð°Ð´Ð¾Ð¼ Ã'€ÐµÐ²Ð¾Ð»Ã'ŽÃ'†Ã'ˆÐ½Ð¾Ð³Ð¾ Ã'ˆÐ´Ã'…одÃ'Æ' в Ã'‚аÃ'€Ð³ÐµÃ'‚нÃ'ˆ геннÃ'ˆ Tepami. Вважаемо за доÃ'‰Ð»Ã'Å'не пÃ'€Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ã' подалÃ'Å'Ã'ˆÐ¸Ã'… комплекÃ'Ð½Ð¸Ã'… доÃ'Ð»Ã'‰Ð¶ÐµÐ½Ã'Å' длÃ' з'Ã'Ã'Ã'Æ'ваннÃ' клÃ'ˆÃ'ˆÐ½Ð¾Ð³Ð¾ поÃ'‚енÃ'‰Ð°Ð»Ã'Æ' Ã'‚а опÃ'‚ималÃ'Å'ниÃ'… Ã'€ÐµÐ¶Ð¸MÄ°B викоÃ'€Ð¸Ã'Ã'‚аннÃ' заÃ'Ð¾Ð±Ã'ˆ на ochobí ангÃ'ŽÃ'Ã'‚аÃ'‚инÃ'Æ' длÃ' лÃ'ˆÃ'Æ'ваннÃ' неоваÃ'ÐºÃ'Æ'лÃ'Ã'€Ð½Ð¸Ã'… паÃ'‚ологÃ'ˆ ока.Alternate abstractАнгиоÃ'Ã'‚аÃ'‚инÃ'‹ Ã'Ð¾Ã'Ã'‚авлÃ'Ã'ŽÃ'‚ гÃ'€Ã'Æ'ппÃ'Æ' кÃ'€Ð¸Ð½Ð³Ð» (К)-Ã'Ð¾ деÃ'€Ð¶Ð°Ã'‰Ð¸Ã'… пÃ'€Ð¾Ã'‚еолиÃ'‚иÃ'‡ÐµÃ'ÐºÐ¸Ã'… Ã'„Ã'€Ð°Ð³Ð¼ÐµÐ½Ã'‚ов плазминоген/плазмина, коÃ'‚оÃ'€Ã'‹Ðµ Ã'„Ã'Æ'нкÃ'†Ð¸Ð¾Ð½Ð¸Ã'€Ã'Æ'Ã'ŽÃ'‚ как моÃ'‰Ð½Ã'‹Ðµ ингибиÃ'€Ã'Æ'Ã'ŽÃ'‰Ð¸Ðµ медиаÃ'‚оÃ'€Ã'‹ пÃ'€Ð¾Ð»Ð¸Ã'„еÃ'€Ð°Ã'†Ð¸Ð¸ и мигÃ'€Ð°Ã'†Ð¸Ð¸ Ã'Ð½Ð´Ð¾Ã'‚елиалÃ'Å'нÃ'‹Ã'… клеÃ'‚ок. АнгиоÃ'Ã'‚аÃ'‚инÃ'‹ Ã'Æ'Ã'‡Ð°Ã'Ã'‚вÃ'Æ'Ã'ŽÃ'‚ в модÃ'Æ'лиÃ'€Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ã'€Ð¾Ã'Ã'‚а Ã'Ð¾Ã'Ã'Æ'дов в Ã'‚канÃ'Ã'… в ноÃ'€Ð¼Ðµ и пÃ'€Ð¸ Ã'€Ð°Ð·Ð»Ð¸Ã'‡Ð½Ã'‹Ã'… паÃ'‚ологиÃ'‡ÐµÃ'ÐºÐ¸Ã'… Ã'Ð¾Ã'Ã'‚оÃ'Ð½Ð¸Ã'Ã'…, аÃ'Ã'Ð¾Ã'†Ð¸Ð¸Ã'€Ð¾Ð²Ð°Ð½Ð½Ã'‹Ã'… Ã' абеÃ'€Ã'€Ð°Ð½Ã'‚ной неоваÃ'ÐºÃ'Æ'лÃ'Ã'€Ð¸Ð·Ð°Ã'†Ð¸ÐµÐ¹. ЦелÃ'Å'Ã'Ž Ã'€Ð°Ð±Ð¾Ã'‚Ã'‹ бÃ'‹Ð»Ð¾ обобÃ'‰ÐµÐ½Ð¸Ðµ имеÃ'ŽÃ'‰ÐµÐ¹Ã'Ã' инÃ'„оÃ'€Ð¼Ð°Ã'†Ð¸Ð¸, вклÃ'ŽÃ'‡Ð°Ã' Ã'Ð¾Ð±Ã'Ã'‚веннÃ'‹Ðµ Ã'ÐºÃ'Ð¿ÐµÃ'€Ð¸Ð¼ÐµÐ½Ã'‚алÃ'Å'нÃ'‹Ðµ даннÃ'‹Ðµ авÃ'‚оÃ'€Ð¾Ð², о пеÃ'€Ã'Ð¿ÐµÐºÃ'‚иваÃ'… пÃ'€Ð¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ã' ангиоÃ'Ã'‚аÃ'‚инов длÃ' леÃ'‡ÐµÐ½Ð¸Ã' неоваÃ'ÐºÃ'Æ'лÃ'Ã'€Ð½Ã'‹Ã'… заболеваний глаза (НÐâ€"Г). ОÃ'Ð½Ð¾Ð²Ð½Ð¾Ðµ внимание Ã'Ð¾Ã'Ã'€ÐµÐ´Ð¾Ã'‚оÃ'‡ÐµÐ½Ð¾ на паÃ'‚ологиÃ'Ã'… Ã'ÐµÃ'‚Ã'‡Ð°Ã'‚ки и повÃ'€ÐµÐ¶Ð´ÐµÐ½Ð¸Ã'Ã'… Ã'€Ð¾Ð³Ð¾Ð²Ð¸Ã'†Ã'‹. Ð’ Ã'‡Ð°Ã'Ã'‚ноÃ'Ã'‚и, опиÃ'Ã'‹Ð²Ð°Ã'ŽÃ'‚Ã'Ã' даннÃ'‹Ðµ лиÃ'‚еÃ'€Ð°Ã'‚Ã'Æ'Ã'€Ã'‹ о пеÃ'€Ã'Ð¿ÐµÐºÃ'‚ивнÃ'‹Ã'… и Ã'€ÐµÃ'‚Ã'€Ð¾Ã'Ð¿ÐµÐºÃ'‚ивнÃ'‹Ã'… иÃ'Ã'Ð»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ã'Ã'…, клиниÃ'‡ÐµÃ'ÐºÐ¸Ã'… иÃ'Ð¿Ã'‹Ã'‚аниÃ'Ã'… и паÃ'‚оÃ'„изиологиÃ'‡ÐµÃ'ÐºÐ¸Ã'… живоÃ'‚нÃ'‹Ã'… моделÃ'Ã'…, Ã'Ð¾Ð·Ð´Ð°Ð½Ð½Ã'‹Ã'… длÃ' иÃ'Ã'Ð»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ã' и леÃ'‡ÐµÐ½Ð¸Ã' НÐâ€"Г. ОÃ'Ð¾Ð±Ã'‹Ð¹ акÃ'†ÐµÐ½Ã'‚ бÃ'‹Ð» Ã'Ð´ÐµÐ»Ð°Ð½ на лабоÃ'€Ð°Ã'‚оÃ'€Ð½Ã'‹Ã'… подÃ'…одаÃ'… к полÃ'Æ'Ã'‡ÐµÐ½Ð¸Ã'Ž Ã'€Ð°Ð·Ð»Ð¸Ã'‡Ð½Ã'‹Ã'… изоÃ'„оÃ'€Ð¼ ангиоÃ'Ã'‚аÃ'‚ина, а Ã'‚акже на Ã'Ã'€Ð°Ð²Ð½ÐµÐ½Ð¸Ð¸ анÃ'‚иангиогеннÃ'‹Ã'… возможноÃ'Ã'‚ей наÃ'‚ивнÃ'‹Ã'… и Ã'€ µÐºÐ¾Ð¼Ð±Ð¸Ð½Ð°Ð½Ã'‚нÃ'‹Ã'… полипепÃ'‚идовангиоÃ'Ã'‚аÃ'‚инов. РезÃ'Æ'лÃ'Å'Ã'‚аÃ'‚Ã'‹ Ã'ÐµÃ'€Ð¸Ð¸ иÃ'Ã'Ð»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ã'Ð²Ð¸Ð´ÐµÃ'‚елÃ'Å'Ã'Ã'‚вÃ'Æ'Ã'ŽÃ'‚, Ã'‡Ã'‚о ангиоÃ'Ã'‚аÃ'‚инÃ'‹ могÃ'Æ'Ã'‚ полноÃ'Ã'‚Ã'Å'Ã'Ž подавлÃ'Ã'‚Ã'Å' паÃ'‚ологиÃ'‡ÐµÃ'ÐºÐ¸Ð¹ ангиогенез пÃ'€Ð¸ диабеÃ'‚иÃ'‡ÐµÃ'ÐºÐ¾Ð¹ пÃ'€Ð¾Ð»Ð¸Ã'„еÃ'€Ð°Ã'‚ивной Ã'€ÐµÃ'‚инопаÃ'‚ии, не влиÃ'Ã' на ноÃ'€Ð¼Ð°Ð

Texto completo: Disponível Coleções: Bases de dados de organismos internacionais Base de dados: ProQuest Central Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Revista: Biotechnologia Acta Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados de organismos internacionais Base de dados: ProQuest Primal Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Revista: Biotechnologia Acta Ano de publicação: 2021 Tipo de documento: Artigo

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Source: https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1136887

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